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Mitochondrial respiratory chain dysfunction modulates metalloproteases 1, 3 and 13 in human normal chondrocytes in culture

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DJ-1 (PARK7), a multifunctional protein associated with early-onset Parkinsons disease (PD) and elevated in cancers, stabilizes Nrf2 by interfering with Nrf2-Keap1 binding to protect against oxidative stress in dopaminergic neurons and cancer cells (72)

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To better resolve the structural details, we generated a mask covering the layer 1 or layer 2 and performed masked local refinement (Supplementary Fig