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[13] In the other five trials (NCT01930188, [69] NCT01885208, [70] NCT02128932, [71] NCT02207374, [72] and NCT02254291 [73] ), participants were randomly assigned to receive either semaglutide or another anti-diabetic medication, and the participant and provider knew which medication was being given in four trials
The main purpose of this article is to review efficacy and safety of cagrilintide with special emphasis on its combination with semaglutide
Semaglutide's mechanism of action mimics a natural hormone in the body called GLP-1 (glucagon-like peptide-1), which is released after eating to help regulate appetite and blood sugar levels
However, large-scale cardiovascular outcome trials for semaglutide have not found a statistically significant increase in the incidence of these conditions in humans